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On Monday 3rd April, during the American Association for Cancer Research (AACR) 2017 annual meeting, a poster (1318 / 19) by Mary L. McMaster, from NCI-DCEG, Bethesda, MD, et al. titled “A genome-wide association study of Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma demonstrates association with chromosomes 6 and 14” was presented.
The group aimed to find common genetic aberrations resulting in susceptibility to Waldenström Macroglobulinemia (WM). They carried out a two-stage Genome-Wide Association study (GWAS) which included more than 450 WM cases and 4,300 controls of European ancestry. Stage 1 (discovery) included 217 cases of WM (40% familial) and 3,798 controls. Stage 2 (replication) included 269 WM or LPL cases (4% familial) and 571 controls.
The poster was concluded by stating that this group’s results provide some understanding of the underlying genetic basis of WM susceptibility.
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