All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
An expert panel hosted by
Sequencing immune-based therapies in B-cell malignancies
with Ulric Jäger, Sagar Lonial, and Krina Patel
Saturday, June 15 | 18:00-19:30 CEST
Register nowThis independent education activity is sponsored by Bristol Myers Squibb. All content is developed independently by the faculty. Funders are allowed no direct influence on the content of this activity.
The Lymphoma Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Lymphoma Hub cannot guarantee the accuracy of translated content. The Lymphoma Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
Bookmark this article
At the American Association for Cancer Research (AACR) annual meeting in Washington, DC, USA, on Tuesday 4th April, a poster session titled “Molecular Medicine” took place.
One of the posters on display (3132 / 21) was titled “Inhibition of the integrin αVβ3 improves the effect of bexarotene in the treatment of cutaneous T-cell lymphoma (CTCL)” by Florencia Cayrol from the Biomedical Research Institute, Buenos Aires, Argentina, and colleagues.
The group aimed to evaluate how the anti-lymphoma activity of bexarotene (BEX) is affected by activation of the classical nuclear Thyroid Hormone Receptor (TR) and the membrane receptor integrin αVβ3 during Thyroid Hormone (TH) replacement therapy.
The effect of cilengitide on the efficacy of BEX is currently being analyzed in murine CTCL models. The poster was concluded by stating that these data indicate that, even in the present of TH replacement therapy, inhibition of the integrin αVβ3 improves the efficacy of bexarotene in CTCL.
Understanding your specialty helps us to deliver the most relevant and engaging content.
Please spare a moment to share yours.
Please select or type your specialty
Subscribe to get the best content related to lymphoma & CLL delivered to your inbox