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This ASCO 2016 oral abstract presentation took place on Sunday June 5, 9:45am–12:45pm, during the ‘Hematologic Malignancies-Lymphoma and Chronic Lymphocytic Leukemia’ session. This session was chaired by Pr Gilles Salles, Head of the Hematology Department in South Lyon hospitals, Lyon, France.
The abstract (#7503) was presented by Dr Mathias J Rummel, head of the Department of Hematology at the Clinic for Hematology and Medical Oncology at the Justus-Liebig University-Hospital, Gießen, Germany.
In FL, maintenance rituximab is a standard care option; however, this is not the case for MCL. A prospective, randomized, multicenter study (NCT00877214) was initiated to investigate observation compared to maintenance rituximab following induction with bendamustine-rituximab in newly diagnosed MCL patients.
Beginning in April 2009, this study’s primary outcome measure was PFS. Inclusion criteria consisted of: stage II (with bulky disease >7 cm), III, or IV disease; CD20+ lymphoma verified by histological analysis; general condition WHO 0–2; and age between 18–80 years.
Induction of up to 6 cycles of bendamustine-rituximab was administered to patients, and the 122 who responded were randomized to either 375mg/m2 rituximab every 2 months for 2 years (n=60) or observation only (n=62).
Once again, the superb efficacy of bendamustine-rituximab was demonstrated in elderly patients with MCL. However, no significant difference in PFS or OS was found between the rituximab maintenance and observation arms. Therefore, it was concluded that there is no evidence to support the use of rituximab maintenance after bendamustine-rituximab in elderly MCL patients. Furthermore, the activity of bendamustine-rituximab without maintenance rituximab appeared comparable to R-CHOP plus maintenance rituximab (PFS and OS).
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