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Sequencing immune-based therapies in B-cell malignancies
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On Monday 3 December 2018, Oral Session 626 took place at the 60th American Society of Hematology (ASH) Annual Meeting, San Diego, CA. During that session, Abstract #781 with the results of the FLYER trial were presented by Viola Poeschel from Saarland University Medical School, Saarland, Germany.
In this phase III trial, the investigators hypothesized that four cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) plus two more rituximab infusions are similarly efficacious to the current standard of care for young non-Hodgkin lymphoma (NHL) patients, of six R-CHOP cycles. The primary endpoint of the trial was 3-year progression-free survival (PFS). Secondary endpoints included, response rates, event-free survival (EFS), overall survival (OS), and safety.
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