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Sequencing immune-based therapies in B-cell malignancies
with Ulric Jäger, Sagar Lonial, and Krina Patel
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On Monday 3 December 2018, Oral Session 642 took place at the 60th American Society of Hematology (ASH) Annual Meeting, San Diego, CA. During that session, results from the phase III iLLUMINATE (PCYC-1130) trial (Abstract #691) were presented by Carol Moreno from the Autonomous University of Barcelona, Barcelona, SP.
In this international, multicenter, randomized, phase III trial two combination regimens were investigated as first-line treatment for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Ibrutinib and obinutuzumab combination was compared to chlorambucil and obinutuzumab for their efficacy and safety. This study is one of the first to compare a chemotherapy-free regimen to chemo-immunotherapy for CLL/SLL patients. The primary endpoint of the study was progression-free survival (PFS) as assessed by an Independent Review Committee (IRC). Secondary endpoints include overall response rate (ORR), overall survival (OS), safety, rate of undetectable minimal residual disease (MRD), and PFS by IRC in the high-risk population.
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