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Pier Luigi Zinzani from the University of Bologna, Italy, and colleagues recently published data from a phase-II study of mogamulizumab in R/R PTCL in a Letter to the Editor of Haematologica in October 2016. Mogamulizumab is approved in Japan for the treatment of CCR4-positive PTCL patients. The authors’ study aimed to primarily assess the ORR of R/R PTCL patients treated with the anti-CCR4 monoclonal antibody, mogamulizumab, in a 15 center, European, phase-II trial. Their secondary outcomes were duration of response, PFS, OS, and safety, and their study enrolled 38 patients of which 35 were included in their analysis.
Zinzani et al. noted that their reported ORR was much lower than a previous study of 29 patients with relapsed CCR4-positive PTCL by Ogura et al. within a Japanese population (11.5% vs 34%). There were many potential reasons given for this difference including that Zinzani et al. included refractory PTCL patients, which are known to have a poorer outcome than relapsed patients. Additionally, the dose in the Ogura et al. study was higher, with 68% of patients receiving the maximum eight doses in eight weeks.
In conclusion, despite a low ORR of 11.4%, there was an SD or better rate of 45.7%. For the future, the authors suggested exploring combination therapies with mogamulizumab in the treatment of R/R PTCL.
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