All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the Lymphoma Coalition.
Introducing
Now you can personalise
your Lymphoma Hub experience!
Bookmark content to read later
Select your specific areas of interest
View content recommended for you
Find out moreThe Lymphoma Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Lymphoma Hub cannot guarantee the accuracy of translated content. The Lymphoma Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
Bookmark this article
On 21st February 2017, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to CMD-003 for patients with R/R Lymphoma and Post-Transplant Lymphoproliferative Disease (PTLD) associated with Epstein Barr Virus (EBV).
Cell Medica’s CMD-003, also known as baltaleucel-T, is a preparation of autologous cytotoxic T-Cells, which have been programmed to target EBV antigens such as EBV Nuclear Antigen (EBVNA), BamHI-A Rightward Frame-1 (BARF1), and Latent Membrane Proteins 1 and 2 (LMP1, LMP2). CMD-003 has the potential to treat and manage a range of EVB associated malignancies such as lymphomas, gastric cancers, and nasopharyngeal carcinoma.
Current, active trials taking place with CMD-003 include the international, open-label, phase II CITADEL trial (NCT01948180), which aims to investigate the efficacy of the immunotherapy in EBV-positive Extranodal NK/T-Cell Lymphoma patients with aggressive disease. The estimated primary completion is December of this year. Moreover, the phase II, open-label, CIVIC trial (NCT02763254) aims to assess the safety and clinical activity of CMD-003 in patients with EBV-positive DLBCL, HL, and PTLD. However, primary results of this trial are not expected to be published until December 2018.
Understanding your specialty helps us to deliver the most relevant and engaging content.
Please spare a moment to share yours.
Please select or type your specialty
Subscribe to get the best content related to lymphoma & CLL delivered to your inbox